This report describes the histopathological features of an ossifying epulis, measuring 1.5 × 1 × 1 cm in length, width and height, respectively, on the lingual surface of the lower jaw of a 2.5 year-old parrot cichlid (Hoplarchus psittacus) from a commercial aquarium.The tumor had appeared in the oral cavity three months prior to its introduction to the laboratory for diagnosis. Grossly, the neoplastic mass was pale-tan with a shiny, smooth surface and coalescing areas of hemorrhage. Microscopically, the overlying epithelium was hyperplastic and extended deeply into the underlying stroma. The stroma consisted of well vascularized collagenous tissue and neoplastic fibroblasts associated with irregular cords and islands of mineral deposition as dentin-like materials confirmed by Masson's trichrome and Goldner's trichrome staining.

Benign mesenchymoma is a soft tissue NEOPLASM that contains 2 or more mature mesenchymal tissues in addition to fibrous tissue. A rare case of GINGIVAL benign mesenchymoma in a 53- year- old man is presented and the clinicopathologic characteristics of this uncommon tumor in the head and neck region is reviewed and discussed.

Background and Aim: Regarding the importance and prevalence of lichen planus among patients and rarity of Oro- Vulval-Vaginal and Peno-GINGIVAL syndromes, that need more attention for diagnosis because of simultaneous oral and genital involvement, we are going to review the symptoms and early diagnosis of these patients. The aim of this article is to report two patients with Oro-Vulval-Vaginal syndrome and two patients with Peno- GINGIVAL syndrome with a short review on these syndromes and their treatments. Case Report: This study is a case report four patients with these syndromes who attended oral medicine department. For each patient a complete document consisting of demographic information, medical, dental, familial and social history was prepared and a photograph was taken from the oral lesions at the first visit and for definite diagnosis of genital lesions consultation with Dermatologist and OB &GYN Surgeon was done. After biopsy and definite diagnosis simultaneous treatment for oral and genital lesions started.Regarding the severity of lesions and acceptable response to the primary treatment, type and dose of the drug was changed and finally the patients were placed in follow up phase.Conclusion: Regarding the outcome of neglecting Lichen Planus in other organs and delay in accurate diagnosis and lack of receiving enough and on time treatment, performing an exact examination and taking a complete history with attention to other organ's symptoms is of great importance. More over malignant changes in even asymptomatic oral and genital lesions is probable.

On encountering an eyelid or orbital mass, apart from common skin lesions, the diagnosis requires systemic evaluation, radiological and eventually histological confirmation. The majority are uncommon conditions for ophthalmologists.1 The presenting signs in all soft tissue NEOPLASMs and carcinomas are rather similar with lid swelling and proptosis. In this edition Langerhans cell histiocytosis (LCH), granular cell tumor (GCT) and eyelid conjunctival amyloidosis have been reported. In all the diagnosis is based on confirmation of an adnexal mass and by imaging followed by a histopathological report along with systemic investigation.

Introduction: Malignant lymphomas are a group of NEOPLASMs affecting lymphoreticular system and are devided into 2 types: Hodgkin’s and Non-hodgkin’s (NHL). Hodgkin’s lymphoma rarely involves extranodal sites but Non-Hodgkin’s lymphoma can be extranodal in 24-48% of cases. Primary oral involvement in NHL is rare and interestingly in 3% of the cases, the only symptom of disease is an enlargement of oral tissue.Case Report: A 40-year-old man presented to Oral Medicine Department of Shahid Beheshti dental school with a chief complaint of GINGIVAL overgrowth following tooth extraction. After incisional biopsy and the diagnosis of NHL, he was referred to Cancer Institute of Imam Khomeini Hospital and chemotherapy regimen was indicated for him, but unfortunately he died in the beginning of the treatment.Conclusion: Although the first presentation of NHL as an intraoral lesion is rare, but recognizing its oral manifestations and timely diagnosis and referral has a prominent influence in prognosis and survival of this group of patients.

BACKGROUND AND AIM: Squamous cell carcinoma (SCC) is usually considered a disease of older people. Recently, there is a change in the occurrence of such lesions in young patients and lacking the established risk factors.CASE REPORT: A 21-year-old male reported with an innocuous GINGIVAL growth over lower incisors since a month. Within 15 days he noticed another GINGIVAL growth in same region lingually. The growths were mildly tender with no suppuration. The associated teeth were non-mobile and vital. The radiographic findings were insignificant. An excisional biopsy was performed under local anesthesia. The stained H and E section showed a hyper-parakeratinized stratified squamous surface epithelium with underlying connective tissue with collagen fibers, fibroblasts, blood vessels and areas of dense chronic inflammatory cell infiltrate. Epithelium exhibited features of dysplasia. There was a breach in the continuity of the basement membrane and the malignant epithelial cells were seen invading the connective tissue in form of thin cord.CONCLUSION: The histopathological study confirmed the diagnosis of well differentiated SCC. Oral SCC is not a disease of the elderly anymore. We also reviewed the literature of SCC in young patients. Thus biopsy is mandatory for any non-resolving GINGIVAL growth.

Thalassemia is an inherited genetic disorder of hemogolobin synthesis. It is Characterized by a quantitative reduction of their alpha or beta chains of globin. It results in an inherited problem in synthesis of a specific type of globin chain either due to deletion of the relevant gene or faulty translation of the genetic information.The onset of the severe from of the disease, homozygous beta thalassemia, occurs insidiously during the first or second year of life.The aim of this study was to evaluate relationship between thalasemia, caries and periodontal problems. A cross-sectional study was designed by evaluating 98 registered patients who had suffering from thalasemia and recieved monthly transfusion, during 1999.Results showed that:Over all 66 male patients, had been involved with an average age of 19.8 years and 32 female patients with an averge age of 155 years.There was a significant difference between those who had splenectomy compare to those who did not recieve this operation by an increase of both GI and DMF scores.

Background and Aim: Benign fibrous histiocytoma (BFH) is a rare oral NEOPLASM particularly in children. Oral BFH is usually painless and found in middle age individuals and mostly affects buccal mucosa. This article describes a case of rare BFH of the oral mucosa that represented high recurrence rate.Case report: The patient reported is a 9-year old girl who was referred for a relatively firm mass about I cm in interdental maxillary incisor. Radiographic examination did not show any particular feature. The mass was excised.Microscopic examination revealed spindle-shaped fibroblastic with vesicular nucleus arranged in fascicule with Storiform pattern, and some histiocyte-like cells. There was no apparent cytologic atypia or any mitotic figures. Evidence suggested benign fibrous histiocytoma (BFH).Conclusion: Although oral benign fibrous histiocytoma (BFH) is a rare lesion, it should be considered in differential diagnosis of oral lesions.

Background: Pancreatic simple cysts are smaller than the complex cysts and are located in distal areas of pancreas. Papillary solid and cystic tumor is a rare NEOPLASM in children and elderly, and often occurs in young women and girls.Case Report: A forty-year-old woman with a history of epigastria pain for five years had referred several times to medical centers was conducted to be candidate to pancreatic systectomy with general anesthesia. She underwent distal pancreatectomy. Patient postoperative follow-up was continued.Conclusion: Papillary solid and cystic tumor of the pancreas is a rare NEOPLASM with unknown origin and often benign. It presents with vague abdominal pain. Ultrasound, magnetic resonance imaging (MRI) and CT-scan would help to make diagnosis before the surgery. Surgery is the choice treatment and the diagnosis would be proved with histology and immunohistochemistry.